NON-ALCOHOLIC FATTY LIVER DISEASE AND EXTRA-HEPATIC CANCER: A NARRATIVE REVIEW
Achiles Queiroz Monteiro de Rezende1, Everton Cazzo1
1Universidade Estadual de Campinas, Departamento de Cirurgia, Campinas, SP, Brasil.
Arquivos De Gastroenterologia
|June 19, 2024
Summary
Non-alcoholic fatty liver disease (NAFLD) is linked to an increased risk of developing various extra-hepatic cancers. This review confirms consistent evidence associating NAFLD with cancers of the colon, stomach, pancreas, breast, prostate, and bladder.
Area of Science:
- Hepatology and Oncology
- Epidemiology of Chronic Diseases
Background:
- Emerging research highlights significant associations between non-alcoholic fatty liver disease (NAFLD) and the development of extra-hepatic cancers.
- Understanding this link is crucial for public health and clinical practice.
Purpose of the Study:
- To conduct a comprehensive review of existing literature on the association between NAFLD and extra-hepatic cancer.
- To synthesize current evidence regarding NAFLD's role in various extra-hepatic malignancies.
Main Methods:
- A narrative literature review was performed using MEDLINE (PubMed) and LILACS (BVS databases).
- Search terms included "fatty liver" and "cancer".
- Original studies investigating NAFLD's impact on extra-hepatic cancers were selected and analyzed.
Main Results:
- The review included nine prospective cohort studies, one retrospective cohort study, three case-control studies, and three cross-sectional studies.
- Data synthesis focused on the relationship between NAFLD and different types of extra-hepatic cancers.
Conclusions:
- Consistent evidence supports a link between NAFLD and extra-hepatic carcinogenesis.
- NAFLD is particularly associated with increased risks of colorectal, gastric, pancreatic, breast, prostate, and bladder cancers.
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