TEN-YEAR OUTCOMES OF TIPS FOR BUDD-CHIARI SYNDROME: SYSTEMATIC REVIEW AND META-ANALYSIS

Area of Science:

• Hepatology
• Interventional Radiology
• Gastroenterology

Background:

• Budd-Chiari syndrome (BCS) involves hepatic venous outflow obstruction, potentially leading to liver cirrhosis.
• Transjugular intrahepatic portosystemic shunt (TIPS) is a potential treatment for a subset of BCS patients.

Purpose of the Study:

• To systematically review and meta-analyze the effectiveness of TIPS in treating BCS.
• To evaluate survival rates, portosystemic pressure reduction, need for liver transplantation, technical failure, and shunt dysfunction up to 10 years post-procedure.

Main Methods:

• A systematic review and meta-analysis of 17 studies involving 618 BCS patients treated with TIPS.
• Data extracted from PubMed, Science Direct, Web of Science, and SCOPUS databases.
• Bias risk assessed using NOS, NHI, and JBI scales; meta-analyses performed using R software.

Main Results:

• A 19% reduction in portosystemic pressure was observed.
• The rates for liver transplantation, technical failure, and shunt dysfunction were 6%, 2%, and 30%, respectively.
• High survival rates were reported: 88% between 1-10 years, 92% at 5 years, and 77% at 10 years.

Conclusions:

• TIPS is an effective treatment for BCS, associated with high long-term survival and significant portosystemic pressure reduction.
• The need for liver transplantation and technical failure rates following TIPS placement for BCS are low.