Related Experiment Video
Updated: Jun 23, 2025
06:08
A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
Published on: March 21, 2025
152
Prostate cancer with elevated free prostate-specific antigen density: A case report
Deng-Hui Huang1, Yun-Xi Hu1, Shuang Guo1
1Department of Urological Surgical, Wenshang County People's Hospital, Jining 272500, Shandong Province, China.
World Journal of Clinical Cases
|June 20, 2024
Summary
This case study highlights prostate cancer in a patient with normal total prostate-specific antigen (tPSA) but elevated free PSA density (fPSAD). This finding offers a clinical reference for diagnosing and treating similar cases.
Area of Science:
- Oncology
- Urology
- Biochemistry
Background:
- Prostate cancer is a prevalent malignancy in men globally.
- Prostate-specific antigen (PSA) is a key biomarker for prostate cancer screening.
- Elevated total PSA (tPSA) typically indicates potential prostate cancer, while normal levels often suggest its absence.
Observation:
- A patient initially diagnosed with benign prostatic hyperplasia underwent prostatectomy.
- Postoperative pathology revealed acinar adenocarcinoma of the prostate.
- The patient presented with a normal tPSA level but an elevated free PSA density (fPSAD).
Findings:
- The case demonstrates prostate cancer can occur despite normal tPSA levels.
- Elevated fPSAD can be a critical indicator in such scenarios.
- This challenges the conventional interpretation of tPSA in prostate cancer screening.
Implications:
- This case provides a valuable clinical reference for diagnosing and managing prostate cancer.
- It underscores the importance of considering fPSAD in conjunction with tPSA for accurate diagnosis.
- Further research may refine PSA-based screening protocols to include fPSAD for improved detection rates.
