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Updated: Jun 23, 2025

Evaluation of the Impact of Protein Aggregation on Cellular Oxidative Stress in Yeast
Published on: June 23, 2018
Proteins clump: Mechanics and transport during neurodegeneration
David Gazzo1, Tamara L Kinzer-Ursem2, Jeremiah J Zartman3
1Department of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana; Bioengineering Graduate Program, University of Notre Dame, Notre Dame, Indiana.
Abstract:
This summary of recent contributions in the Biophysical Journal from 2020 to 2023 highlights new mechanistic insights into key biomechanical and biophysical aspects of neurodegeneration. Neurodegeneration encompasses complex diseases characterized by the progressive loss of neuronal function, often linked to protein accumulation and aggregation. Several factors, including mechanical properties and structural composition of brain tissue, formation of proteinaceous condensates within cells, and protein transport between cells, impact the loss of neural function.
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