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Published on: July 31, 2016
[Intraperitoneal chemotherapy for colorectal cancer peritoneal metastasis]
1Department of General Surgery (Colorectal Surgery), the Sixth Affiliated Hospital, Sun Yat-sen University;Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases, The Sixth Affiliated Hospital, Sun Yat-sen University;Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University,Guangdong Province Biomedical Material Conversion and Evaluation Engineering Technology Center, Guangzhou 510655, China.
Intraperitoneal chemotherapy offers promising treatment options for colorectal cancer peritoneal metastasis. Further research is needed to optimize its application and improve patient outcomes.
Area of Science:
- Oncology
- Surgical Oncology
- Gastrointestinal Oncology
Background:
- Peritoneal metastasis is a common and poor prognostic indicator for colorectal cancer.
- Current treatment relies on cytoreductive surgery and systemic chemotherapy, with intraperitoneal chemotherapy as a key supplement.
Purpose of the Study:
- To review the development, modalities, and current status of intraperitoneal chemotherapy for colorectal cancer peritoneal metastasis.
- To highlight areas for future research to standardize and enhance treatment efficacy.
Main Methods:
- Review of existing literature on intraperitoneal chemotherapy modalities.
- Analysis of treatment approaches including HIPEC, NIPS, EPIC, SPIC, NIPEC, and PIPAC.
- Discussion of research needs for optimizing agent selection, timing, and protocols.
Main Results:
- Intraperitoneal chemotherapy encompasses diverse methods like HIPEC and PIPAC.
- Standardization requires further investigation into mechanisms, agents, and administration protocols.
- Sequential intraperitoneal chemotherapy feasibility needs exploration.
Conclusions:
- Intraperitoneal chemotherapy presents a significant therapeutic avenue for colorectal cancer peritoneal metastasis.
- Continued research is crucial for refining techniques and improving clinical application.
- Optimizing intraperitoneal chemotherapy will enhance management of this challenging condition.
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