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Updated: Jun 23, 2025

A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells
Published on: August 29, 2020
Regulating epithelial-mesenchymal plasticity from 3D genome organization
Qing You Pang1, Yi-Chia Chiu2, Ruby Yun-Ju Huang3,4,5
1Neuro-Oncology Research Laboratory, National Neuroscience Institute, Singapore, 308433, Singapore.
Abstract:
Epithelial-mesenchymal transition (EMT) is a dynamic process enabling polarized epithelial cells to acquire mesenchymal features implicated in development and carcinoma progression. As our understanding evolves, it is clear the reversible execution of EMT arises from complex epigenomic regulation involving histone modifications and 3-dimensional (3D) genome structural changes, leading to a cascade of transcriptional events. This review summarizes current knowledge on chromatin organization in EMT, with a focus on hierarchical structures of the 3D genome and chromatin accessibility changes.
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