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EMT and cancer: what clinicians should know
Erik W Thompson1,2, Andrew D Redfern3, Simone Brabletz4
1School of Biomedical Sciences, Faculty of Health, Queensland University of Technology, Brisbane, Queensland, Australia. e2.thompson@qut.edu.au.
Nature Reviews. Clinical Oncology
|July 22, 2025
Summary
Cancer cell plasticity, driven by epithelial-mesenchymal transition (EMT), fuels metastasis and treatment resistance. Understanding EMT
Area of Science:
- Oncology
- Cell Biology
Background:
- Cell plasticity is key to cancer progression, metastasis, and treatment resistance.
- The epithelial-mesenchymal transition (EMT) program is a major driver of cancer cell plasticity.
- EMT is linked to increased cancer mortality and resistance to various therapies.
Purpose of the Study:
- To review clinical evidence for EMT's role in cancer progression and patient outcomes.
- To discuss clinical opportunities and challenges in targeting EMT for cancer therapy.
Main Methods:
- Review of extensive data from cell line and animal models.
- Analysis of clinical studies correlating EMT biomarkers with disease progression and mortality.
- Synthesis of current knowledge on EMT's impact on cancer treatment.
Main Results:
- Clinical evidence supports EMT's role in various cancer stages.
- EMT is associated with disease progression and patient mortality.
- EMT contributes to resistance against major cancer treatment modalities.
Conclusions:
- Epithelial-mesenchymal plasticity is a significant factor in cancer.
- Targeting EMT presents opportunities for novel cancer therapies and management strategies.
- Further research is needed to translate EMT knowledge into improved therapeutic outcomes.
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