Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cell Migration01:19

Cell Migration

4.8K
Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
4.8K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.7K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.7K
Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

2.7K
Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
2.7K
Actin Polymerization and Cell Motility01:13

Actin Polymerization and Cell Motility

5.2K
Actin is a family of globular proteins that are highly abundant in eukaryotic cells. It makes up approximately 1-5% of total cell protein concentration. Actin monomers polymerize to form a complex network of polarized filaments, the actin cytoskeleton, that plays a crucial role in many cellular processes, including cell motility, division, endocytosis, and metastasis of cancer cells.
Actin cytoskeleton dynamics can produce pushing, pulling, and resistance forces that help the cell to migrate....
5.2K
Role of Myosin in Cell Migration01:18

Role of Myosin in Cell Migration

2.3K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II  is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.3K
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nuclear adaptation in cell migration.

Current opinion in cell biology·2026
Same author

Quantitative live imaging reveals PRICKLE1 controls junctional neural tube morphogenesis independent of Planar Cell Polarity.

Nature communications·2026
Same author

Developmental organization of sensory and sympathetic ganglia.

Nature·2026
Same author

Response to: "Neonatal Autonomic and Adrenocorticotropic Features in the Offspring of Mothers in the Gestational Diabetes".

Archives of medical research·2026
Same author

Mechanical confinement induces ferroptosis through mitochondrial dysfunction.

Nature communications·2025
Same author

Late Vitamin K Deficiency Bleeding in Infancy: The Time to Ensure Effective Prevention.

Nutrition reviews·2025
Same journal

Disentangling the response to lysosomal damage.

Journal of cell science·2026
Same journal

The force, form and function of the nucleus.

Journal of cell science·2026
Same journal

The nucleus-vacuole junction at a glance.

Journal of cell science·2026
Same journal

Loss of INPP5E affects photoreceptor outer segment membrane biogenesis in iPSC-derived human retinal organoids.

Journal of cell science·2026
Same journal

Brinker regulates reciprocal outcomes of BMP signal between stem cells and differentiating cells.

Journal of cell science·2026
Same journal

Primary cilium disassembly - from mechanisms to roles in physiology and disease.

Journal of cell science·2026
See all related articles

Related Experiment Video

Updated: Jun 23, 2025

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K

Perspectives in collective cell migration - moving forward.

Samantha J Stehbens1,2, Elena Scarpa3, Melanie D White2,4

  • 1The University of Queensland, Australian Institute for Bioengineering and Nanotechnology, St Lucia, Brisbane, QLD 4072, Australia.

Journal of Cell Science
|June 21, 2024
PubMed
Summary
This summary is machine-generated.

Collective cell migration is crucial for development and cancer. New imaging and models reveal how the microenvironment influences cell movement, offering insights into tissue formation and metastasis.

Keywords:
Cell biologyCollective cell migrationMetastasisModellingMorphogenesis

More Related Videos

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.5K
Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

6.9K

Related Experiment Videos

Last Updated: Jun 23, 2025

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration
10:53

Traction Microscopy Integrated with Microfluidics for Chemotactic Collective Migration

Published on: October 13, 2019

7.0K
Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration
11:43

Concentric Gel System to Study the Biophysical Role of Matrix Microenvironment on 3D Cell Migration

Published on: April 3, 2015

8.5K
Using the Dot Assay to Analyze Migration of Cell Sheets
09:42

Using the Dot Assay to Analyze Migration of Cell Sheets

Published on: December 5, 2017

6.9K

Area of Science:

  • Cell Biology
  • Biophysics
  • Mathematical Biology

Background:

  • Collective cell migration is fundamental to morphogenesis and cancer metastasis.
  • Recent advances in imaging and modeling are elucidating the cell-microenvironment interplay.
  • Understanding cell polarity, metabolism, and migration modes is key.

Purpose of the Study:

  • To provide a perspective on recent discoveries in collective cell migration.
  • To highlight emerging themes and challenges in the field.
  • To suggest future directions for research.

Main Methods:

  • Integration of advanced imaging techniques.
  • Application of biophysical and mathematical modeling.
  • Interdisciplinary collaboration between biology, physics, and mathematics.

Main Results:

  • Collective cell migration can occur in fluid-like or static states.
  • The microenvironment significantly shapes cell behavior and migration patterns.
  • Models offer novel insights into coordinated cell movement.

Conclusions:

  • Continued interdisciplinary research is essential to decode complex collective cell migration.
  • Understanding collective migration is vital for comprehending tissue organization.
  • Insights into collective cell migration can inform cancer metastasis research.