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A Case Series of Delusional Infestation in Huntington's Disease

Wenxin Song1, Lauren Daneman2, Alexis Cohen-Oram2

  • 1USF Health Morsani College of Medicine, Tampa, FL, USA.

Journal of Huntington'S Disease
|June 21, 2024
PubMed

Insights

Huntington

Area of Science:

  • Neuroscience
  • Psychiatry
  • Genetics

Background:

  • Huntington's disease (HD) is a neurodegenerative disorder caused by CAG repeats in the huntingtin gene.
  • Delusional infestation (DI) is a rare psychotic symptom that can occur in patients with Huntington's disease.

Observation:

  • This report details two middle-aged female patients diagnosed with both Huntington's disease and delusional infestation.
  • The first patient's DI responded to olanzapine and later risperidone, but relapses occurred.
  • The second patient's DI resolved with risperidone, iron repletion, and amantadine discontinuation, though other psychotic symptoms persisted.

Findings:

  • Treatment responses for delusional infestation in Huntington's disease can vary.
  • Antipsychotic medications like olanzapine and risperidone show potential in managing DI in HD patients.
  • Adjunctive therapies and medication adjustments may influence treatment outcomes.

Implications:

  • These cases highlight the importance of recognizing and managing delusional infestation in Huntington's disease.
  • Understanding treatment efficacy for DI in HD can guide clinical practice.
  • Further research is needed to optimize therapeutic strategies for this uncommon comorbidity.

Keywords:
Huntington’s diseasedelusioninfestationneurologyparasitosispsychiatry

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