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Updated: Aug 19, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
11:17

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Treatment of skin and soft tissue infections with imipenem/cilastatin

R J Fass, E H Freimer, R V McCloskey

    The American Journal of Medicine
    |June 7, 1985
    PubMed

    Insights

    Imipenem/cilastatin, cefazolin, and moxalactam effectively treated skin infections in 97% of patients. These antibiotics eradicated most bacteria, even those resistant in lab tests, with good tolerability.

    Area of Science:

    • Infectious Diseases
    • Pharmacology
    • Clinical Medicine

    Background:

    • Skin and soft tissue infections (SSTIs) represent a significant clinical challenge.
    • Evaluating the efficacy and tolerability of broad-spectrum antibiotics is crucial for managing SSTIs.

    Purpose of the Study:

    • To assess the clinical effectiveness and safety of imipenem/cilastatin, cefazolin, and moxalactam in treating adult patients with SSTIs.
    • To determine the impact of in vitro antibiotic resistance on clinical outcomes.

    Main Methods:

    • A multicenter study involving 98 adult patients diagnosed with bacterial SSTIs.
    • Patients were treated with imipenem/cilastatin (n=71), cefazolin (n=21), or moxalactam (n=6).
    • Clinical response and pathogen eradication rates were evaluated.

    Main Results:

    • A high favorable clinical response rate of 97% (87/90 evaluable cases) was observed across all treatment groups.
    • Most causative bacterial pathogens were eradicated, including strains showing in vitro resistance to the administered antibiotic.
    • Adverse reactions were minimal and did not show specific patterns across the three agents.

    Conclusions:

    • Imipenem/cilastatin, cefazolin, and moxalactam are highly effective and well-tolerated treatments for bacterial SSTIs.
    • These antibiotics demonstrate efficacy even against certain pathogens with in vitro resistance, highlighting their clinical utility.
    • The study supports the use of these agents in managing a variety of SSTIs.

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