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Chorionic villus sampling for first-trimester prenatal diagnosis: Northwestern University program
American Journal of Obstetrics and Gynecology
|May 15, 1985
Summary
Developing a chorionic villus sampling (CVS) program showed initial success. Operator experience positively impacted sample quality and cytogenetic analysis reliability for early pregnancy diagnosis.
Area of Science:
- Medical Genetics
- Obstetrics and Gynecology
Background:
- Chorionic villus sampling (CVS) is a prenatal diagnostic technique.
- Establishing a reliable CVS program requires careful methodology and quality assessment.
Purpose of the Study:
- To report the initial experience in developing a CVS program at Northwestern University.
- To assess the reliability and reproducibility of CVS for cytogenetic analysis.
Main Methods:
- Phase 1 involved CVS in 58 patients undergoing first-trimester abortion to evaluate sample adequacy and cytogenetic methods (direct vs. culture).
- Specimens were quality-categorized (Class I-III).
- Phase 2 involved CVS in continuing pregnancies after IRB approval.
Main Results:
- A positive trend was observed between operator experience, villus quantity, and cytogenetic preparation quality.
- In the first 20 cases of continuing pregnancies, two chromosomal abnormalities were detected (47,XY,+13 and 45,X).
Conclusions:
- The initial experience demonstrates the feasibility of establishing a CVS program.
- Operator experience is crucial for obtaining adequate samples and reliable cytogenetic results.
- Recommendations are provided for developing a comprehensive CVS program.