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Related Concept Videos

Studying the Cytoskeleton01:17

Studying the Cytoskeleton

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The cytoskeletal architecture can be studied using different microscopic and biochemical techniques. Electron microscopy was instrumental in discovering the cytoskeletal architecture around the 1960s, which allowed obtaining structural information at a high-resolution level. However, the sample preparation procedure often limits this ability in biological samples. Several protocols have been developed over the years to optimize sample preparation. In one of the protocols known as rotary...
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Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Adaptability of Cytoskeletal Filaments01:12

Adaptability of Cytoskeletal Filaments

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The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
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Introduction to the Cytoskeleton01:33

Introduction to the Cytoskeleton

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Overview of the Cytoskeleton
The cytoskeleton is a network of protein filaments present within the cell, having three distinct filaments ̶   microfilaments, microtubules, and intermediate filaments. Each has characteristic features that distinguish them, including the dynamics of their assembly and disassembly, mechanical properties, polarity, and the type of molecular motors associated with them. Earlier, they were thought to be present only in eukaryotic cells; however, their...
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Cytoskeletal Accessory Proteins01:13

Cytoskeletal Accessory Proteins

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The cytoskeleton is an essential cell component that plays several structural and functional roles. However, the filaments that make up the cytoskeleton cannot function independently and depend on the accessory or ancillary proteins to effectively carry out their function. Accessory proteins associate with cytoskeletal filaments and their monomers, aiding filament formation and function. They also help in the cross-communication among cytoskeletal filaments. Cytoskeletal accessory proteins are...
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Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

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Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...
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Related Experiment Video

Updated: Jun 23, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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Cytoskeleton-modulating nanomaterials and their therapeutic potentials.

Jinwon Park1, Yina Wu1, Jung Suk Kim1

  • 1College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea.

Advanced Drug Delivery Reviews
|June 21, 2024
PubMed
Summary

Nanomaterials offer novel therapeutic strategies by modulating the cytoskeleton, a key cellular network. This approach targets diseases like cancer and neurodegeneration, promising advanced medical treatments.

Keywords:
ActinCancerCytoskeletonMicrotubuleNanomaterialsNeurodegenerative diseases

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Area of Science:

  • Cell Biology
  • Nanotechnology
  • Biomedical Engineering

Background:

  • The cytoskeleton is crucial for cell structure, motility, and intracellular transport.
  • Cytoskeletal dysfunction is implicated in diseases such as cancer and neurodegenerative disorders.
  • Targeting the cytoskeleton presents a promising avenue for therapeutic intervention.

Purpose of the Study:

  • To review the role of nanomaterials in modulating the cytoskeleton for therapeutic applications.
  • To explore the mechanisms, progress, challenges, and future directions in this interdisciplinary field.

Main Methods:

  • Review of current research on inorganic (gold, metal oxides, carbon, black phosphorus) and organic (peptides, proteins) nanomaterials.
  • Discussion of nanomaterials with responsive properties (magnetic, light) for targeted cytoskeletal manipulation.
  • Analysis of direct interaction with cytoskeletal components and modulation of signaling pathways.

Main Results:

  • Nanomaterials can directly interact with cytoskeletal proteins or influence related cellular pathways.
  • Responsive nanomaterials enable precise, controlled modulation of the cytoskeleton, minimizing off-target effects.
  • Diverse nanomaterial types offer varied mechanisms for cytoskeletal manipulation.

Conclusions:

  • Cytoskeleton-targeting nanomaterials represent a cutting-edge approach for developing novel disease therapies.
  • Advancements in responsive nanomaterials enhance therapeutic precision and efficacy.
  • Continued research holds significant promise for integrating nanotechnology and medicine to combat a wide range of diseases.