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Related Concept Videos

Contact-dependent Signaling01:19

Contact-dependent Signaling

44.6K
Contact-dependent signaling, as the name suggests, requires that communicating cells be in direct contact with each other. This is achieved either through receptor-ligand interactions or by specialized cytoplasmic channels that allow the flow of small molecules between cells. In animal cells, channels called gap junctions facilitate contact-dependent signaling in certain tissues, whereas, plasmodesmata perform a similar function in plants.
Gap Junctions
In animal cells, gap junctions are formed...
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T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
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Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

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Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
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Cell Adhesion Molecules - Types and Functions01:20

Cell Adhesion Molecules - Types and Functions

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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
CAM Families
The Integrin family of proteins is primarily  involved...
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Overview of Cell Signaling01:23

Overview of Cell Signaling

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate with the environment.
Cells respond to many types of information, often through receptor proteins positioned on the membrane. For example, skin cells respond to and transmit touch...
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What is Cell Signaling?02:03

What is Cell Signaling?

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Despite the protective membrane that separates a cell from the environment, cells need the ability to detect and respond to environmental changes. Additionally, cells often need to communicate with one another. Unicellular and multicellular organisms use a variety of cell signaling mechanisms to communicate to respond to the environment.
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Related Experiment Video

Updated: Jun 23, 2025

Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells
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Mechanical Stimulation-induced Calcium Wave Propagation in Cell Monolayers: The Example of Bovine Corneal Endothelial Cells

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Unveiling contact-mediated cellular crosstalk.

Hyobin Kim1, Kwang-Eun Kim2, Esha Madan3

  • 1Department of Computational Biomedicine, Cedars-Sinai Medical Center, West, Hollywood, CA, USA.

Trends in Genetics : TIG
|June 21, 2024
PubMed
Summary
This summary is machine-generated.

Cell-cell communication is vital for organism function and disrupted in disease. New spatial transcriptomics and computational methods reveal how cell proximity impacts gene expression and cellular responses.

Keywords:
cell–cell contactcell–cell interactionsgene expression changes

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Related Experiment Videos

Last Updated: Jun 23, 2025

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A Co-culture Method to Investigate the Crosstalk Between X-ray Irradiated Caco-2 Cells and PBMC
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Area of Science:

  • Cell biology
  • Systems biology
  • Genomics

Background:

  • Cell-cell interactions form regulatory networks essential for multicellular organism function.
  • Disruption of these interactions is linked to various disease states.
  • Understanding cell communication is crucial for biological and medical research.

Purpose of the Study:

  • To review cutting-edge approaches for studying cell-cell communication.
  • To highlight advancements in analyzing gene expression based on cell proximity.
  • To explore computational methods for deciphering cellular responses to cell contact.

Main Methods:

  • Single-cell sequencing
  • Spatial transcriptomics
  • Bioengineering tools
  • Molecular tools
  • Computational approaches

Main Results:

  • Spatial transcriptomics enables analysis of gene expression changes relative to cell proximity.
  • New tools provide a deeper understanding of how cells respond to each other.
  • Computational methods are advancing the interpretation of cell contact-mediated responses.

Conclusions:

  • Technological advancements have revolutionized the study of cell-cell interactions.
  • Spatial transcriptomics offers unique insights into the impact of cell proximity on cellular behavior.
  • Integrated approaches are key to deciphering complex cell communication networks.