Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phagocytic defense in the lung.

H Y Reynolds

    Antibiotics and Chemotherapy
    |January 1, 1985
    PubMed
    Summary

    Lung defense relies on alveolar macrophages and neutrophils. Opsonins, like IgG subclasses, enhance phagocytosis, but cystic fibrosis complicates this. Future therapies may involve targeted antibody replacement and active immunization strategies.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Review and perspective of the 12th Bronchoalveolar Lavage Conference within the second joint WASOG-BAL International Conference.

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2011
    Same author

    Bronchoalveolar lavage--obtaining biologic specimens from the respiratory tract surface.

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2008
    Same author

    Bronchoalveolar lavage: perspective from the 11th BAL conference.

    Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace·2008
    Same author

    Sarcoidosis: impact of other illnesses on the presentation and management of multi-organ disease.

    Lung·2002
    Same author

    Sampling local respiratory tract sites for inflammation.

    Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG·2001
    Same author

    Use of bronchoalveolar lavage in humans--past necessity and future imperative.

    Lung·2001

    Area of Science:

    • Immunology
    • Pulmonology
    • Cellular Biology

    Background:

    • Lung defense involves alveolar macrophages and polymorphonuclear neutrophils (PMNs).
    • Phagocytosis, the engulfment of pathogens, is crucial for containing intruders.
    • Opsonins, such as immunoglobulin G (IgG), enhance phagocytic efficiency.

    Purpose of the Study:

    • To explore the complex interplay of immune and non-immune opsonins in lung defense.
    • To address the challenges posed by proteolytic enzymes in cystic fibrosis (CF) that degrade antibodies.
    • To discuss the potential of targeted humoral replacement therapies, including intravenous IgG and monoclonal antibodies.

    Main Methods:

    • Review of existing literature on phagocytic cells and opsonin function in the lung.
    • Analysis of the impact of CF on antibody integrity and opsonization.
    • Discussion of strategies for selective antibody subclass production and delivery.

    Main Results:

    • IgG antibodies, particularly specific subclasses, are important for immune-mediated phagocytosis by macrophages.
    • Proteolytic enzymes in CF patients degrade antibodies, complicating opsonization and phagocytosis.
    • Intravenous IgG and monoclonal antibodies offer potential for passive immune therapy.

    Conclusions:

    • Developing effective active immunization strategies requires further research in animal models.
    • Targeting mucosal surfaces for immunization presents unique challenges compared to systemic administration.
    • Future directions include manipulating humoral immune responses for selective immunoglobulin subclass production to enhance lung defense.

    Related Experiment Videos