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Author Spotlight: Decoding DNA Repair by Extrachromosomal NHEJ Assay and HR Assays
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DNA mismatch repair system expression in salivary gland tumors: A Systematic Review

G-M-T-T Alves1, R-J Severino-Lazo, G-K Amaral-Silva

  • 1Integrated Anatomic Pathology Center Oswaldo Cruz University Hospital University of Pernambuco (UPE) R. Arnóbio Marques, 310 Santo Amaro Recife - PE, 50100-130, Brazil marianne.carvalho@upe.br.

Medicina Oral, Patologia Oral Y Cirugia Bucal
|June 22, 2024
PubMed
Abstract

Insights

Reduced expression of DNA mismatch repair (MMR) proteins is linked to salivary gland tumors (SGTs). This suggests a correlation between MMR protein levels and the development of both benign and malignant SGTs.

Area of Science:

  • Genomics
  • Oncology
  • Molecular Biology

Background:

  • The DNA mismatch repair (MMR) system is crucial for genomic stability.
  • Dysregulation of MMR is implicated in oncogenesis.
  • Reduced MMR protein expression is observed in salivary gland tumors (SGTs).

Purpose of the Study:

  • To analyze the expression of MMR proteins in SGTs.
  • To discuss the association between MMR protein expression and SGT development.

Main Methods:

  • Systematic review following PRISMA guidelines.
  • Comprehensive literature search across multiple databases (PubMed, Web of Science, Scopus, Embase, ProQuest).
  • Methodological quality assessed using JBI's Critical Appraisal Tool.

Main Results:

  • Included 142 patients with benign SGTs and 84 with malignant SGTs.
  • Literature analysis revealed reduced expression of MMR proteins (hHMS2, hMLH1, hMSH3, hMSH6).
  • Reduction observed in the percentage of marked cells.

Conclusions:

  • Reduced MMR protein expression correlates with the development of SGTs.
  • Further research is needed to precisely measure biomarker protein expression.

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