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Updated: Jun 23, 2025
Method for the Assessment of Effects of a Range of Wavelengths and Intensities of Red/near-infrared Light Therapy on Oxidative Stress In Vitro
Published on: March 21, 2015
Blue light irradiation suppresses oral squamous cell carcinoma through induction of endoplasmic reticulum stress and
Hui Jiang1, Qiqi Fu2, Jiali Yang2
1Academy for Engineering and Technology, Fudan University, 220th Handan Road, Shanghai 200433, China.
Abstract:
The therapeutic potential of blue light photobiomodulation in cancer treatment, particularly in inhibiting cell proliferation and promoting cell death, has attracted significant interest. Oral squamous cell carcinoma (OSCC) is a prevalent form of oral cancer, necessitating innovative treatment approaches to improve patient outcomes. In this study, we investigated the effects of 420 nm blue LED light on OSCC and explored the underlying mechanisms. Our results demonstrated that 420 nm blue light effectively reduced OSCC cell viability and migration, and induced G2/M arrest. Moreover, we observed that 420 nm blue light triggered endoplasmic reticulum (ER) stress and mitochondrial dysfunction in OSCC cells, leading to activation of the CHOP signal pathway and alterations in the levels of Bcl-2 and Bax proteins, ultimately promoting cell apoptosis. Additionally, blue light suppressed mitochondrial gene expression, likely due to its damage to mitochondrial DNA. This study highlights the distinct impact of 420 nm blue light on OSCC cells, providing valuable insights into its potential application as a clinical treatment for oral cancer.
Insights
Blue light photobiomodulation effectively inhibits oral squamous cell carcinoma (OSCC) growth by inducing cell death. This 420 nm blue light therapy shows promise for treating oral cancer by targeting cancer cell proliferation and survival mechanisms.
Area of Science:
- Oncology
- Biophotonics
- Cell Biology
Background:
- Oral squamous cell carcinoma (OSCC) presents a significant challenge in oral cancer treatment.
- Innovative therapeutic strategies are crucial for improving patient outcomes in OSCC.
- Photobiomodulation using blue light is emerging as a potential cancer therapy.
Purpose of the Study:
- To investigate the anti-cancer effects of 420 nm blue light on OSCC cells.
- To elucidate the underlying molecular mechanisms of blue light-induced OSCC cell death.
- To assess the potential of blue light as a novel clinical treatment for oral cancer.
Main Methods:
- Treatment of OSCC cells with 420 nm blue LED light.
- Assessment of cell viability, migration, and cell cycle progression (G2/M arrest).
- Analysis of endoplasmic reticulum (ER) stress, mitochondrial dysfunction, apoptosis-related proteins (Bcl-2, Bax), and mitochondrial gene expression.
Main Results:
- 420 nm blue light significantly reduced OSCC cell viability and migration.
- Blue light induced G2/M cell cycle arrest and promoted apoptosis.
- Mechanisms involved ER stress, mitochondrial dysfunction, CHOP pathway activation, and altered Bcl-2/Bax ratios.
- Suppressed mitochondrial gene expression, potentially via mitochondrial DNA damage.
Conclusions:
- 420 nm blue light exhibits potent anti-cancer effects against OSCC cells.
- The therapeutic action involves inducing cellular stress, apoptosis, and inhibiting proliferation.
- Blue light photobiomodulation offers a promising avenue for clinical application in oral cancer treatment.
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