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Related Concept Videos

Longitudinal Research02:20

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Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
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Related Experiment Video

Updated: Jun 23, 2025

Methodology for Establishing a Community-Wide Life Laboratory for Capturing Unobtrusive and Continuous Remote Activity and Health Data
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Call to action for a life course approach.

David Simmons1, Yashdeep Gupta2, Teri L Hernandez3

  • 1School of Medicine, Western Sydney University, Sydney, NSW, Australia.

Lancet (London, England)
|June 23, 2024
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Summary

Gestational diabetes (GDM) management needs a life course approach, from preconception to postpartum. Early diagnosis and intervention, integrated into antenatal care, can improve outcomes for mothers and offspring.

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Area of Science:

  • Obstetrics and Gynecology
  • Endocrinology
  • Public Health

Background:

  • Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication with significant maternal and offspring health implications.
  • Current management often focuses on late-stage interventions, necessitating a shift towards a more comprehensive strategy.

Purpose of the Study:

  • To advocate for a personalized, integrated life course approach to GDM management, encompassing preconception, pregnancy, and postpartum care.
  • To highlight the benefits of early GDM diagnosis and intervention, ideally before 14 weeks of gestation.
  • To emphasize the need for integrating early screening into routine antenatal care and reducing care variations globally.

Main Methods:

  • Review of current literature and clinical guidelines on GDM pathophysiology, diagnosis, and management.
  • Analysis of the benefits of early lifestyle interventions and timely postpartum follow-up.
  • Discussion of strategies for integrating GDM care into broader family health and utilizing precision medicine for prevention programs.

Main Results:

  • Early pregnancy lifestyle interventions show potential in preventing GDM.
  • Early diagnosis and treatment before 14 weeks of gestation are associated with improved outcomes.
  • Postpartum oral glucose tolerance tests and regular screening for dysglycaemia and cardiometabolic disease are crucial.
  • Personalized medicine and shared decision-making can enhance diabetes prevention programs for women with prior GDM.

Conclusions:

  • A paradigm shift towards a life course approach is essential for effective GDM management.
  • Integrating early screening, personalized interventions, and regular postpartum follow-up can mitigate the global burden of GDM.
  • Addressing barriers to preventative care and treatment across diverse healthcare settings is critical.