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Characterization of Pediatric Patch Testing: A Retrospective Review, 2020-2023

Caroline Brumley1,2, Puneet Arora1,2, Sara A Hylwa1,3,4

  • 1From the Department of Dermatology, Park Nicollet Health Services, Minneapolis, Minnesota, USA.

Dermatitis : Contact, Atopic, Occupational, Drug
|June 24, 2024
PubMed

Insights

Pediatric allergic contact dermatitis (ACD) affects children and adults similarly. Key allergens include fragrances and emulsifiers, with some not on standard North American testing series.

Area of Science:

  • Dermatology
  • Allergology
  • Pediatric Health

Background:

  • Allergic contact dermatitis (ACD) affects children and adults, yet pediatric cases are underrepresented in patch testing studies.
  • Limited data exists on specific pediatric ACD prevalence and common allergens.
  • Children constitute less than 10% of patch testing subjects, necessitating focused pediatric research.

Purpose of the Study:

  • To characterize a pediatric cohort undergoing patch testing at a North American center.
  • To identify common allergens and sensitization rates in children with suspected ACD.
  • To analyze the relevance of personal products and non-standard allergens in pediatric ACD.

Main Methods:

  • Retrospective chart review of 135 patients aged 1-17 years tested between July 2020 and August 2023.
  • Data stratified by age groups: 1-5, 6-11, and 12-17 years.
  • Significance-Prevalence Index Numbers (SPIN) calculated for allergen relevance.

Main Results:

  • 86% of pediatric patients were sensitized, with 40% experiencing relevant reactions.
  • Positivity rates were equal between males and females.
  • Top allergens included linalool hydroperoxides, propylene glycol, limonene hydroperoxides, fragrance mix I, and lanolin. Emulsifiers and fragrances were key categories.

Conclusions:

  • ACD affects pediatric males and females equally.
  • 14% of identified top allergens were not on the standard North American Contact Dermatitis Group series.
  • Testing with supplemental allergens and personal products is crucial for accurate pediatric ACD diagnosis.

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