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Angiosarcoma: clinical outcomes and prognostic factors, a single-center analysis
Siyer Roohani1,2,3, Titus Rotermund4, Felix Ehret4,5
1Department of Radiation Oncology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. siyer.roohani@charite.de.
Journal of Cancer Research and Clinical Oncology
|June 24, 2024
Summary
Older age and metastatic angiosarcoma (AS) at diagnosis are linked to poorer survival outcomes. Further research and multi-institutional collaboration are needed to improve treatment for this rare cancer.
Area of Science:
- Oncology
- Surgical Pathology
- Cancer Research
Background:
- Angiosarcomas (AS) are rare, aggressive vascular tumors with challenging prognoses.
- Understanding prognostic factors is crucial for optimizing patient management and treatment strategies.
Purpose of the Study:
- To investigate oncological outcomes, including overall survival (OS) and local progression-free survival (LPFS), in patients with angiosarcomas.
- To identify key prognostic factors influencing the survival of AS patients.
Main Methods:
- Retrospective cohort study of 118 histopathologically confirmed angiosarcoma cases.
- Analysis included primary, locally recurrent, and metastatic AS.
- Kaplan-Meier and multivariable Cox regression analyses were used to assess survival and identify prognostic factors.
Main Results:
- Older age and metastatic disease at presentation were significantly associated with worse OS and LPFS.
- Locally recurrent disease also negatively impacted LPFS.
- Tumor size, epithelioid component, margin status, and perioperative therapies did not show significant associations with OS or LPFS.
Conclusions:
- Older age and metastatic disease are independent negative prognostic factors for angiosarcoma.
- Multi-institutional collaboration, molecular characterization, and novel perioperative therapies are essential to improve outcomes for angiosarcoma patients.
