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Author Spotlight: Exploring Strategies for Successful Immune Response Against Tumors
Published on: August 16, 2024
Strategies for the development of metalloimmunotherapies
Xiaoqi Sun1,2,3, Xingwu Zhou4,5, Xiaoyue Shi4,5
1Department of Pharmaceutical Sciences, University of Michigan, Ann Arbor, MI, USA. sunxqi@umich.edu.
Abstract:
Metal ions play crucial roles in the regulation of immune pathways. In fact, metallodrugs have a long record of accomplishment as effective treatments for a wide range of diseases. Here we argue that the modulation of interactions of metal ions with molecules and cells involved in the immune system forms the basis of a new class of immunotherapies. By examining how metal ions modulate the innate and adaptive immune systems, as well as host-microbiota interactions, we discuss strategies for the development of such metalloimmunotherapies for the treatment of cancer and other immune-related diseases.
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