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Updated: Jun 23, 2025
Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
Interplay between caveolin-1 and mineralocorticoid receptor in cardiometabolic disease
Katarzyna Czarzasta1, Luminita H Pojoga2
1Department of Experimental and Clinical Physiology, Laboratory of Center for Preclinical Research, Medical University of Warsaw, Warszawa, Poland.
Abstract:
Over the past decades, research has clearly established the important role of the mineralocorticoid receptor (MR) in both renal and extra-renal tissues. Recently, caveolin-1 (Cav-1) has emerged as a mediator of MR signaling in several tissues, with implications on cardiovascular and metabolic dysfunction. The main structural component of caveolae (plasma membrane invaginations with diverse functions), Cav-1 is a modulator of cardiovascular function, cellular glucose, and lipid homeostasis, via its effects on signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present evidence indicating an overlap between the roles of the MR and Cav-1 in cardiometabolic disease and the relevant signaling pathways involved. Furthermore, we discuss the potential use of Cav-1 as a biomarker and/or target for MR-mediated dysfunction.
Insights
Mineralocorticoid receptor (MR) and caveolin-1 (Cav-1) play key roles in cardiometabolic diseases. This review explores their overlapping functions and potential as therapeutic targets.
Area of Science:
- Cardiovascular biology
- Metabolic signaling
- Molecular medicine
Background:
- The mineralocorticoid receptor (MR) is crucial in renal and extra-renal tissues.
- Caveolin-1 (Cav-1), a structural protein of caveolae, influences cardiovascular function and metabolic homeostasis.
- MR and Cav-1 signaling pathways are implicated in cardiovascular and metabolic dysfunction.
Purpose of the Study:
- To review the overlapping roles of MR and Cav-1 in cardiometabolic diseases.
- To elucidate the signaling pathways involved in MR- and Cav-1-mediated effects.
- To discuss the potential of Cav-1 as a biomarker or therapeutic target for MR dysfunction.
Main Methods:
- Literature review of studies on MR and Cav-1 in cardiometabolic disease.
- Analysis of signaling pathways linking MR and Cav-1.
- Synthesis of evidence on the clinical implications of their interaction.
Main Results:
- Evidence suggests significant overlap in the functions of MR and Cav-1 in cardiometabolic disease.
- Both MR and Cav-1 modulate inflammatory responses and oxidative stress.
- Cav-1 influences cellular glucose and lipid homeostasis.
Conclusions:
- MR and Cav-1 signaling pathways are interconnected in the pathogenesis of cardiometabolic diseases.
- Cav-1 represents a potential biomarker and therapeutic target for conditions involving MR dysfunction.
- Further research is warranted to explore therapeutic strategies targeting Cav-1 in MR-mediated diseases.
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