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Updated: May 6, 2026

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
07:52

Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma

Published on: January 9, 2019

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[Diffuse large B-cell lymphoma with heart involvement: the relevance of the multidisciplinary and multiparameter

Andrea Pennacchioni1, Maria Elena Nizzoli2, Massimo Roncali3

  • 1U.O. Cardiologia, AUSL - IRCCS Reggio Emilia.

Giornale Italiano Di Cardiologia (2006)
|June 25, 2024
PubMed

Insights

Lymphoma patients face cardiac risks from treatment and infiltration. This study details the successful multidisciplinary management of diffuse large B-cell lymphoma with heart involvement, detected via imaging.

Area of Science:

  • Cardiology
  • Oncology
  • Medical Imaging

Background:

  • Lymphoma patients are susceptible to cardiovascular events from anthracycline cardiotoxicity and cardiac infiltration.
  • Cardiac masses in lymphoma patients complicate management, posing risks of arrhythmias, heart block, ischemia, and effusion.

Purpose of the Study:

  • To describe the clinical presentation of lymphoma with multifocal cardiac involvement.
  • To highlight the successful multidisciplinary management of such cases.

Main Methods:

  • Case report of diffuse large B-cell lymphoma with cardiac involvement.
  • Utilized total body 18FDG positron emission tomography for disease staging.
  • Employed a multidisciplinary approach for patient management.

Main Results:

  • Successfully managed a case of diffuse large B-cell lymphoma with multifocal cardiac involvement.
  • 18FDG PET imaging was crucial for identifying cardiac infiltration at staging.
  • Multidisciplinary care led to a positive outcome.

Conclusions:

  • Multifocal cardiac involvement in lymphoma is a complex clinical challenge.
  • Early identification via advanced imaging like 18FDG PET is vital.
  • Multidisciplinary management is key to successful outcomes in these high-risk patients.

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