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Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis III01:31

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Pulmonary Tuberculosis IV01:26

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Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
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Pulmonary Tuberculosis II01:28

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Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
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Pulmonary Tuberculosis V01:28

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Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
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Open Angle Glaucoma: Treatment

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
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Evaluation of Serum Zonulin Levels and Their Association with the Clinical Course of Brucellosis.

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Ocular Involvement in Patients with Brucellosis: A Single-Center Prospective Study.

Murat Aydin1, Ahmet Duhan Özbay2, Nurten Nur Aydin1

  • 1Department of Infectious Diseases and Clinical Microbiology, Erzurum Regional Education and Research Hospital, Erzurum, Turkey.

Ocular Immunology and Inflammation
|June 25, 2024
PubMed
Summary

Ocular brucellosis affects nearly 25% of patients, with conjunctivitis being most common. Prompt ophthalmologic exams are vital for early detection and treatment, leading to good outcomes.

Keywords:
Brucellabrucellosisconjunctivitisocular involvementuveitis

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Rheumatology

Background:

  • Brucellosis is a zoonotic infection with potential systemic manifestations.
  • Ocular involvement is a recognized, though less common, complication of brucellosis.
  • Understanding the spectrum and outcomes of ocular brucellosis is crucial for patient management.

Purpose of the Study:

  • To determine the prevalence, types, and treatment outcomes of ocular involvement in patients diagnosed with brucellosis.
  • To identify clinical and laboratory factors associated with ocular manifestations in brucellosis patients.

Main Methods:

  • A prospective, single-center study included 242 patients diagnosed with brucellosis.
  • Ophthalmologic examinations were conducted at baseline and during follow-up (1, 3, and 6 months).
  • Brucellosis diagnosis was confirmed via clinical symptoms and serological tests or blood culture.

Main Results:

  • Ocular involvement was observed in 24.8% of patients, with conjunctivitis (16.1%) and uveitis (5.8%) being most frequent.
  • Patients with ocular involvement were older and presented with higher rates of weight loss and spondylodiscitis.
  • Elevated erythrocyte sedimentation rate and lactate dehydrogenase levels were associated with ocular brucellosis.

Conclusions:

  • Brucellosis frequently presents with ocular complications, underscoring the need for comprehensive evaluation.
  • Early ophthalmologic assessment is critical for timely diagnosis and effective management of ocular brucellosis.
  • The majority of ocular findings in brucellosis patients show significant improvement with treatment.