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Proteases in the Emory mouse cataract.

A A Swanson, R M Davis, N C Meinhardt

    Investigative Ophthalmology & Visual Science
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Protease activity in mouse lenses differs between cataract-prone and resistant strains. Emory Mouse cataractous lenses showed higher specific activity for certain proteases, but resistant mouse lenses had greater overall protease activity.

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    Area of Science:

    • Biochemistry
    • Ophthalmology
    • Proteomics

    Background:

    • Proteases play crucial roles in cellular processes, including lens transparency.
    • Alterations in protease activity are implicated in the pathogenesis of cataracts.

    Purpose of the Study:

    • To investigate and compare the activity of specific exopeptidases and endopeptidases in cataractous and resistant mouse lenses.
    • To identify potential protease markers associated with cataract development.

    Main Methods:

    • Extraction of lens proteins from Emory Mouse (cataractous) and Cataract Resistant mouse models.
    • Assay of dipeptidyl peptidase III (DPP III) activity using Arg-Arg-2-NNap substrate.
    • Assay of prolyl endopeptidase activity using Boc-Arg-Pro-2-NNap substrate.
    • Assay of leucine aminopeptidase activity using beta-naphthylamide substrate.

    Main Results:

    • Dipeptidyl peptidase III and prolyl endopeptidase activities were elevated in Emory Mouse cataractous lens extracts compared to controls.
    • Leucine aminopeptidase exhibited high hydrolysis rates in both mouse groups.
    • Cataract Resistant mouse lenses demonstrated approximately double the overall protease activity compared to Emory Mouse cataractous lenses.

    Conclusions:

    • Specific protease activities, including DPP III and prolyl endopeptidase, are altered in cataractogenesis.
    • While certain proteases are upregulated in cataractous lenses, overall protease activity is higher in resistant mouse lenses, suggesting a complex role for proteases in cataract development.