Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Assembly of Cytoskeletal Filaments

Assembly of Cytoskeletal Filaments

Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...

The Replisome

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A study protocol for mixed-methods evaluation of the structure, design, and availability of medical student wellbeing programs.

PloS one·2026

Same author

Mitochondrial dynamics in prostatic cells during seasonal hyperplasia and atrophy in wild ground squirrels (Spermophilus dauricus).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology·2026

Same author

Validation of a torsinA cerebellar knockdown model of DYT1 dystonia.

Dystonia (Lausanne, Switzerland)·2026

Same author

Deep learning-based automated segmentation and quantification of aortic arch calcification at chest radiograph.

BMC geriatrics·2026

Same author

Seasonal dynamics of vitamin D metabolism in the oviduct of the Chinese Brown frog (Rana dybowskii).

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology·2026

Same author

Fucoidans as multifunctional marine polysaccharide platforms: From nutritional supplements to advanced drug delivery for cancer therapy.

International journal of pharmaceutics: X·2026

Same journal

On-Cell Detection of Polysaccharide One-Bond <sup>1</sup>J<sub>CH</sub> Couplings by Proton-Detected Solid-State NMR.

Journal of the American Chemical Society·2026

Same journal

Correction to "Unraveling the Effects of Fe Incorporation on High-Performance Water-Splitting Photoanodes".

Journal of the American Chemical Society·2026

Same journal

Proximity-Driven Protein Ligation Beyond the Concentration Limit.

Journal of the American Chemical Society·2026

Same journal

GraPhAI: Neural Networks for Solving Centrosymmetric Crystal Structures.

Journal of the American Chemical Society·2026

Same journal

Probing Stage Transition Kinetics in Li-Graphite Intercalation Compounds by Time-Resolved In Situ Solid-State NMR via <sup>13</sup>C Labeling.

Journal of the American Chemical Society·2026

Same journal

Dynamic Covalent Programming at DNA Base-Pairing Interfaces.

Journal of the American Chemical Society·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 23, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Self-Replicating DNA-Based Nanoassemblies.

Nahida Akter¹, B Safeenaz Alladin-Mustan¹, Yuning Liu¹

¹Department of Chemistry, University of Alberta, Edmonton T6G 2G2, Canada.

Journal of the American Chemical Society

|June 25, 2024

Summary

This summary is machine-generated.

Researchers developed a new method for self-replication of DNA wireframe nanoassemblies using lesion-induced DNA amplification (LIDA). This breakthrough enables the creation of complex DNA nanostructures, mimicking life

More Related Videos

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Related Experiment Videos

Last Updated: Jun 23, 2025

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Folding and Characterization of a Bio-responsive Robot from DNA Origami

Published on: December 3, 2015

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

Area of Science:

Biomimetic DNA nanotechnology
Synthetic biology
Nanomaterials science

Background:

DNA's properties enable programmed self-assembly for nanomaterial construction.
Replicating complex DNA origami and wireframe nanoassemblies is a significant challenge.

Purpose of the Study:

To develop a strategy for self-replication of DNA wireframe nanoassemblies.
To explore the use of isothermal ligase chain reaction lesion-induced DNA amplification (LIDA) for DNA nanotechnology.

Main Methods:

Designed a self-replicating DNA triangle wireframe structure.
Utilized cross-catalysis with a linear analog and complementary fragments containing an abasic lesion.
Employed isothermal ligase chain reaction lesion-induced DNA amplification (LIDA).

Main Results:

Achieved rapid, sigmoidal self-replication of the designed wireframe triangle.
Demonstrated self-replication of a hybrid wireframe triangle with synthetic vertices.
Successfully replicated circular DNA using the same cross-catalytic strategy.

Conclusions:

Isothermal ligase chain reactions, like LIDA, are suitable for self-replicating complex DNA architectures.
This work advances biomimetic DNA nanotechnology by incorporating self-replication.
Opens possibilities for creating self-replicating nanomaterials.