Dynamical changes of interaction across functional brain communities during propofol-induced sedation
Shengpei Wang1,2, Tianzuo Li3, Huiguang He1,2,4
1Laboratory of Brain Atlas and Brain-Inspired Intelligence, Institute of Automation, Chinese Academy of Sciences, No. 95 Zhongguancun East Rd, Haidian District, Beijing 100190, PR China.
Cerebral Cortex (New York, N.Y. : 1991)
|June 25, 2024
Summary
Propofol sedation increases whole-brain network functional interaction, particularly at higher doses. Key brain regions like the posterior cingulate cortex become important hubs, correlating with sedation levels.
Area of Science:
- Neuroscience
- Anesthesiology
- Network Science
Background:
- Understanding anesthetic effects on brain networks is crucial for sedation mechanisms.
- Propofol's impact on functional integration, segregation, and community structure remains unclear.
Purpose of the Study:
- Investigate propofol's effects on whole-brain network topology.
- Examine changes in functional integration and segregation with increasing propofol concentrations.
Main Methods:
- Resting-state fMRI in 12 healthy subjects at 5 propofol concentrations (0-2.0 μg/ml).
- Construction of whole-brain functional networks and community structure identification.
- Analysis of global and local network topological properties and key node alterations.
Main Results:
- Global participation significantly increased at high propofol concentrations, mediated by the bilateral postcentral gyrus.
- Connector hubs emerged in the posterior cingulate cortex and precentral gyrus at high concentrations.
- Nodal participation coefficients of connector hubs correlated with sedation levels.
Conclusions:
- Increasing propofol dosage enhances functional interaction within whole-brain networks.
- Specific brain regions act as critical hubs whose activity relates to sedation depth.
- Findings offer insights into network-level mechanisms of propofol-induced sedation.
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