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Related Experiment Videos

Complement effector mechanisms in health and disease.

N R Cooper, G R Nemerow

    The Journal of Investigative Dermatology
    |July 1, 1985
    PubMed
    Summary

    The complement system, crucial for immunity, can directly recognize pathogens without antibodies, acting as a natural surveillance system. New assays offer specific and quantitative detection of complement activation, improving disease diagnostics.

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    Area of Science:

    • Immunology
    • Biochemistry

    Background:

    • The complement system is a key effector in immunity, mediating cell lysis and activating immune cells.
    • Traditionally viewed as an effector, recent evidence shows complement can directly recognize pathogens without antibodies.

    Purpose of the Study:

    • To highlight the dual role of the complement system in both effector functions and innate immune recognition.
    • To review advancements in specific and quantitative assays for detecting complement activation.

    Main Methods:

    • Review of existing literature on complement system functions.
    • Categorization of novel complement activation assays based on detection principles: proteolysis, new antigens, and protein complexes.

    Main Results:

    • The complement system acts as a natural surveillance mechanism, recognizing pathogens independently of specific immunity.
    • New assays offer superior specificity and sensitivity for detecting complement activation compared to traditional methods.

    Conclusions:

    • The complement system plays a vital role in innate immunity and pathogen surveillance.
    • Advanced assays for complement activation are crucial for accurate diagnosis and understanding of immune responses.

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