Crosstalk between CXCL12/CXCR4/ACKR3 and the STAT3 Pathway
Zelong Ma1, Faxiao Zhou1, Hua Jin1
1Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming 650500, China.
Cells
|June 26, 2024
Summary
The CXCL12/CXCR4/ACKR3 axis and STAT3 pathway interact, influencing disease and tumor progression. Understanding this crosstalk offers new therapeutic targets for cancer treatment.
Area of Science:
- Oncology
- Molecular Biology
- Cell Signaling
Background:
- The CXCL12/CXCR4/ACKR3 axis and STAT3 pathway are implicated in disease and tumor progression.
- Reciprocal modulation between these pathways is a key factor in disease pathogenesis.
Purpose of the Study:
- To systematically review the intricate regulatory mechanisms between the CXCL12/CXCR4/ACKR3 axis and STAT3 signaling.
- To explore the implications of this crosstalk in various diseases, with a focus on neoplasms.
- To identify potential clinical applications and therapeutic targets for novel tumor therapies.
Main Methods:
- Systematic literature review.
- Analysis of molecular mechanisms governing the interplay between CXCL12/CXCR4/ACKR3 and STAT3 signaling.
- Evaluation of preclinical and clinical data related to this axis in disease contexts.
Main Results:
- The CXCL12/CXCR4/ACKR3 axis activates STAT3 through diverse mechanisms.
- STAT3 signaling reciprocally regulates the expression of CXCL12.
- This crosstalk is a significant driver in the progression of various diseases, particularly cancers.
Conclusions:
- The reciprocal interaction between the CXCL12/CXCR4/ACKR3 axis and STAT3 pathway is critical in disease and tumor development.
- Targeting this crosstalk presents promising therapeutic strategies for cancer treatment.
- Further research into these molecular mechanisms can lead to novel targeted therapies.
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