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Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

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Updated: Jun 23, 2025

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Author Spotlight: Advancements in Molecular Biomarker Testing for Non-Squamous Non-Small Cell Lung Cancer

Published on: September 8, 2023

Clinical Applications of Comprehensive Genomic Profiling in Advanced Non-Small-Cell Lung Cancer-A Case Series.

Chun-Ming Tsai^1,2, Chih-Hung Lin¹, Yu-Yen Chou¹

¹Department of Chest Medicine, Cathay General Hospital, Taipei City 112, Taiwan.

Current Oncology (Toronto, Ont.)

|June 26, 2024

Summary

Comprehensive genomic profiling (CGP) using liquid biopsies complements tissue testing for advanced non-small-cell lung cancer (NSCLC). This approach provides clinically useful information to guide personalized treatment decisions and optimize patient outcomes.

Area of Science:

Oncology
Genomics
Molecular Diagnostics

Background:

Keywords:

case series cfDNA guardant 360 liquid biopsy non-small cell lung cancer

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Advanced non-small-cell lung cancer (NSCLC) treatment increasingly relies on targeted therapies based on tumor genetics.

Tissue-based genomic testing faces challenges including inadequate sample availability and invasive procedures.

Liquid biopsies, utilizing circulating cell-free DNA (cfDNA), are recognized to complement tissue testing for NSCLC.