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Renal Vein Thrombosis Secondary to Pyelonephritis: Targeting a Thrombo-Inflammatory Entity
Dimitris Kounatidis1, Vasileios Papadimitropoulos1, Natalia Vallianou1
12nd Department of Internal Medicine, Hippokration University Hospital, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Clinics and Practice
|June 26, 2024
Summary
Pyelonephritis (PN) can lead to renal vein thrombosis (RVT), a rare complication. Early consideration of RVT is crucial for patients with PN unresponsive to antibiotics, requiring anticoagulation for favorable outcomes.
Area of Science:
- Nephrology
- Infectious Diseases
- Vascular Medicine
Background:
- Renal vein thrombosis (RVT) is uncommon, often linked to nephrotic syndrome.
- Pyelonephritis (PN) is a rare but potential predisposing factor for secondary RVT.
Observation:
- This report details a 74-year-old female with RVT secondary to Klebsiella pneumoniae PN.
- A review of 11 PubMed-documented cases of PN complicated by RVT (40-year span) was conducted.
Findings:
- RVT should be suspected in PN patients unresponsive to antibiotics.
- Anticoagulation therapy for 3-6 months is typically required, with a generally favorable prognosis.
- The role of thrombo-inflammation in sepsis-associated RVT was elaborated.
Implications:
- Highlights the importance of considering RVT in refractory pyelonephritis.
- Emphasizes diagnostic and therapeutic strategies for PN-associated RVT.
- Underscores the significance of understanding thrombo-inflammation in infectious contexts.
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