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Repurposing metformin as a potential anticancer agent using in silico technique.

Mona Mahfauz1, Ozel Yuruker2, Rasime Kalkan3

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Metformin, a diabetes drug, shows promise as an anticancer agent. This study identified specific genes in cancer cell lines sensitive to metformin, suggesting potential for targeted cancer therapies.

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Area of Science:

  • Oncology
  • Pharmacology
  • Bioinformatics

Background:

  • Metformin, a common diabetes medication, is being investigated for repurposing as an anticancer drug due to observed correlations with reduced cancer morbidity and mortality.
  • Numerous studies and clinical trials are exploring metformin's potential anticancer applications.

Purpose of the Study:

  • To investigate the potential of metformin as a cancer treatment using pathway/gene-set analysis.
  • Utilized Gene2drug, Gene Ontology (GO), and DepMap databases to assess metformin's efficacy against cancer.

Main Methods:

  • Analyzed 1826 tumor cell lines using the Drug Sensitivity (Primary Purposing Primary Screening) 19Q4 Tool.
  • Employed pathway/gene-set analysis for comprehensive evaluation.

Main Results:

  • Identified 9 specific genes (SGPL1, CXCR6, ATXN2L, LAMP3, RTN3, BTN2A1, FOXM1, NQO1, and L1TD1) out of 402 that demonstrated statistical sensitivity to metformin across the analyzed cancer cell lines.
  • The analysis included 1826 distinct cancer cell lines.

Conclusions:

  • This in-silico study highlights the sensitivity of certain cancer cell lines to metformin.
  • Findings suggest promising avenues for metformin-based and tumor-targeted treatment strategies.
  • Further research is recommended to elucidate metformin's precise mechanism of action and confirm its therapeutic effectiveness in cancer.