Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

1.9K
Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
1.9K
Polymer Classification: Stereospecificity01:26

Polymer Classification: Stereospecificity

2.4K
Polymerization generates chiral centers along the entire backbone of a polymer chain. Accordingly, the stereochemistry of the substituent group has a significant effect on polymer properties. Polymers formed from monosubstituted alkene monomers feature chiral carbons at every alternate position in the polymer backbone. Relative to the predominant orientation of substituents at the adjacent chiral carbons, the polymer can exist in three different configurations: isotactic, syndiotactic, and...
2.4K
Alkylation of β-Diester Enolates: Malonic Ester Synthesis01:14

Alkylation of β-Diester Enolates: Malonic Ester Synthesis

3.4K
Malonic ester synthesis is a method to obtain α substituted carboxylic acids from ꞵ-diesters such as diethyl malonate and alkyl halides.
3.4K
Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

2.1K
The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
2.1K
Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

3.4K
Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
3.4K
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis01:07

Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis

3.3K
Acetoacetic ester synthesis is a method to obtain ketones from alkyl halides and β-keto esters. The reaction occurs in the presence of an alkoxide base that abstracts the acidic proton of the β-keto esters. The step results in an enolate ion which is doubly stabilized. The enolate then reacts with an alkyl halide via the SN2 process to produce an alkylated ester intermediate with a new C–C bond. The hydrolysis of the intermediate, followed by acidification, results in an...
3.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrochemical reduction of unsaturated carbon-carbon bonds via 3d transition-metal catalysis.

Beilstein journal of organic chemistry·2026
Same author

Recent developments in In(III) coordination complexes: singularity in structure-photophysics relationships.

Dalton transactions (Cambridge, England : 2003)·2026
Same author

Impact of waste-derived ethanol on growth and metabolic allocation in black soldier fly larvae: Implications for organic waste treatment.

Journal of environmental management·2026
Same author

Understanding Urea-Linked Dicatechol Chemistry for Developing Micrometer-Thick Surface Coatings.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Synergistic electrocatalysis in a Ag<sub>2</sub>S@MoS<sub>2</sub> nanocomposite enables an ultrasensitive label-free immunosensor of prostate specific antigen.

Analytical methods : advancing methods and applications·2026
Same author

Effect of <i>para</i>-aryl-substituted <i>N</i>-phenyl groups on the photophysical properties of highly fluorescent dibenzo[<i>c</i>,<i>g</i>]carbazole-based chromophores.

RSC advances·2026

Related Experiment Video

Updated: Jun 23, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.4K

Chiral Acetal-Based Stereo-Controlled Degradable Polymer Synthesis.

Dayong Song1, Bonwoo Koo1, Houng Kang2

  • 1Department of Chemistry, Chungbuk National University, 1 Chungdae-ro, Seowon-gu, Cheongju, 28644, Republic of Korea.

Chemistry (Weinheim an Der Bergstrasse, Germany)
|June 26, 2024
PubMed
Summary

Researchers developed stereo-controlled degradable polymers using cascade enyne metathesis polymerization and asymmetric catalysis. This breakthrough enables chiral acetal-based polymers for advanced biomedical and electronic applications.

Keywords:
Asymmetric hydroaminationDegradable polymerLiving polymerizationMetathesis polymerizationStereo-controlled polymer

More Related Videos

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

21.7K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Related Experiment Videos

Last Updated: Jun 23, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
12:07

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning

Published on: April 16, 2018

13.4K
Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction
11:17

Synthesis of Programmable Main-chain Liquid-crystalline Elastomers Using a Two-stage Thiol-acrylate Reaction

Published on: January 19, 2016

21.7K
Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly
09:34

Synthesis of Information-bearing Peptoids and their Sequence-directed Dynamic Covalent Self-assembly

Published on: February 6, 2020

7.2K

Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Organic Synthesis

Background:

  • Precise synthesis of chiral polymers is a significant challenge.
  • Development of degradable polymers is crucial for eco-friendly and advanced materials.
  • Chiral polymers are vital for biomedical and electronic applications.

Purpose of the Study:

  • To introduce a novel method for synthesizing stereo-controlled degradable polymers.
  • To create chiral acetal-based polymers with controlled stereochemistry and degradability.
  • To review the background, development, and potential applications of these polymers.

Main Methods:

  • Cascade enyne metathesis polymerization.
  • Enantioselective acetal synthesis via Palladium-catalyzed asymmetric hydroamination.
  • Stereo-controlled polymerization techniques.

Main Results:

  • Successful synthesis of chiral acetal-based polymers.
  • Demonstrated control over polymer stereochemistry.
  • Achieved polymer degradability.

Conclusions:

  • The developed approach offers a new route to stereo-controlled degradable polymers.
  • These polymers show potential for drug delivery and electronic applications.
  • This work advances the field of chiral polymer synthesis.