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Understanding maternal sepsis risk factors and bacterial etiology: A case control study protocol
Kelly Thompson1,2, Duy Pham Thanh3, Jane E Hirst4
1The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Plos One
|June 26, 2024
Summary
This study investigates maternal sepsis in Vietnam, focusing on risk factors and antimicrobial resistance (AMR). Understanding these elements is crucial for improving care for mothers experiencing sepsis.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Microbiology
Background:
- Maternal sepsis is a significant global health issue, ranking as the third leading cause of sepsis worldwide.
- Antimicrobial resistance (AMR) is an increasing concern in bacteria responsible for maternal sepsis.
- This study protocol addresses the need to understand maternal sepsis etiology and risk factors in a tertiary care setting.
Purpose of the Study:
- To describe the protocol for a clinical and microbiology study on maternal sepsis.
- To investigate the risk factors contributing to maternal sepsis.
- To determine the bacterial etiology and AMR profiles in maternal sepsis cases.
Main Methods:
- A case-control study involving 100 cases and 200 controls at Tu Du Hospital, Vietnam.
- Inclusion criteria: Women aged ≥ 18 years, ≥ 28 weeks gestation, with sepsis from labor onset up to 42 days postpartum.
- Sepsis definition: Suspected/confirmed infection, modified SOFA score ≥ 2, antimicrobial treatment, and requested cultures.
Main Results:
- This section will present findings on risk factors for maternal sepsis.
- The study will detail the frequency of adverse outcomes associated with maternal sepsis.
- Bacterial etiology and AMR profiles of cases and controls will be elucidated.
Conclusions:
- The study will enhance understanding of maternal sepsis epidemiology and management in Vietnam.
- Findings will inform whether current care is optimal and identify areas for improvement.
- This research is vital for addressing maternal sepsis and AMR in the region.
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