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Updated: Jun 23, 2025

Generation and Isolation of Cell Cycle-arrested Cells with Complex Karyotypes
Published on: April 13, 2018
Patterns of Aneuploidy and Signaling Consequences in Cancer
Nadja Zhakula-Kostadinova1,2, Alison M Taylor1,3
1Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York.
Abstract:
Aneuploidy, or a change in the number of whole chromosomes or chromosome arms, is a near-universal feature of cancer. Chromosomes affected by aneuploidy are not random, with observed cancer-specific and tissue-specific patterns. Recent advances in genome engineering methods have allowed the creation of models with targeted aneuploidy events. These models can be used to uncover the downstream effects of individual aneuploidies on cancer phenotypes including proliferation, apoptosis, metabolism, and immune signaling. Here, we review the current state of research into the patterns of aneuploidy in cancer and their impact on signaling pathways and biological processes.
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