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Related Experiment Video

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Optical Trapping of Nanoparticles

Optical Trapping of Nanoparticles

Published on: January 15, 2013

Thermo-Optoplasmonic Single-Molecule Sensing on Optical Microcavities.

Nikita A Toropov^1,2,3, Matthew C Houghton^1,4, Deshui Yu⁵

¹Department of Physics and Astronomy, University of Exeter, Exeter EX4 4QD, U.K.

|June 26, 2024

Summary

This summary is machine-generated.

Optoplasmonic sensors using whispering-gallery-mode (WGM) resonators detect single molecules. The sensing mechanism shifts from reactive (red shifts) to thermo-optoplasmonic (blue shifts) with increasing WGM intensity.

Keywords:

absorption microresonator plasmon protein sensor tryptophan

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Area of Science:

Optics and Photonics
Biophysics
Nanotechnology

Background:

Whispering-gallery-mode (WGM) resonators are crucial for ultrasensitive biological and biochemical detection.
Optoplasmonic sensors, combining WGM resonators with plasmonic nanostructures, achieve single atomic ion sensitivity.

Purpose of the Study:

To investigate the influence of WGM intensity on optoplasmonic sensor response to single-molecule binding.
To differentiate between reactive and thermo-optoplasmonic (TOP) sensing mechanisms.

Main Methods:

Experimental investigation of seven different molecules and complexes using optoplasmonic sensors.
Analysis of WGM resonance wavelength shifts under varying WGM intensities.
Development of a physical model for TOP sensing.

Main Results:

Protein molecule attachment induces red shifts in WGM resonance at low intensity (reactive sensing).
At high intensity, blue shifts are observed due to the thermo-optoplasmonic (TOP) effect, where absorbed light generates heat.
Observed blue shifts for dye molecules and amino acids; noted anomalous near-infrared absorption in enzymes.

Conclusions:

The response of optoplasmonic sensors is intensity-dependent, revealing distinct reactive and TOP sensing regimes.
TOP sensing offers a novel mechanism for single-molecule detection and characterization.
The proposed TOP sensing model facilitates the development of single-molecule absorption spectrometers.