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PC Gene Affects Milk Production Traits in Dairy Cattle
Aixia Du1, Zijiao Guo1, Ao Chen1
1Department of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratory of Animal Genetics, National Engineering Laboratory for Animal Breeding, State Key Laboratory of Animal Biotech Breeding, China Agricultural University, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Beijing 100193, China.
Genes
|June 27, 2024
Summary
Genetic analysis identified six single-nucleotide polymorphisms (SNPs) in the PC gene associated with milk production traits in dairy cattle. These SNPs can aid genomic selection for improved milk yield and quality in Chinese Holstein cows.
Area of Science:
- Animal Genetics
- Dairy Science
- Molecular Biology
Background:
- Previous research indicated differential expression of the PC gene across lactation stages in cows.
- The PC gene was proposed as a candidate for influencing milk production traits in dairy cattle.
Purpose of the Study:
- To investigate polymorphisms in the PC gene.
- To determine the genetic association between PC gene polymorphisms and milk production traits.
- To elucidate the functional mechanism of a specific PC polymorphism on gene transcription.
Main Methods:
- Resequencing of the PC gene to identify polymorphisms.
- Association analysis using an animal model in a cattle population.
- Dual-luciferase reporter assay to assess transcriptional activity.
Main Results:
- Six single-nucleotide polymorphisms (SNPs) were detected in the PC gene.
- All identified SNPs showed significant associations with five milk production traits (p < 0.05).
- Allele G at 29:g.44965658 was found to inhibit PC transcriptional activity by affecting GATA1 binding.
Conclusions:
- The PC gene exerts a significant genetic influence on milk production traits in dairy cattle.
- Six identified SNPs in the PC gene are potential markers for genomic selection (GS).
- These markers can facilitate accelerated genetic improvement of milk yield and quality in Chinese Holstein cows.
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