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Alexander Friedenstein, Mesenchymal Stem Cells, Shifting Paradigms and Euphemisms.

Donald G Phinney1

  • 1Department of Molecular Medicine, Herbert Wertheim UF Scripps Institute for Biomedical Innovation and Technology, Jupiter, FL 33458, USA.

Bioengineering (Basel, Switzerland)
|June 27, 2024
PubMed
Summary
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Friedenstein

Area of Science:

  • Stem cell biology
  • Regenerative medicine
  • Bone marrow research

Background:

  • Mesenchymal stem cells (MSCs) were first identified by Friedenstein six decades ago.
  • His work also aided in identifying hematopoietic stem cells and skeletal stem/progenitor cells (SSPCs).
  • This review commemorates Friedenstein's birth centenary.

Purpose of the Study:

  • To review Friedenstein's key contributions to stem cell research.
  • To discuss the evolving concept and terminology of MSCs.
  • To highlight the link between MSC stromal quality and stem/progenitor functions.

Main Methods:

  • Literature review of Friedenstein's seminal papers.
  • Analysis of the evolving paradigms in MSC research.
  • Discussion of recent findings on MSC stromal attributes.
Keywords:
hierarchymesenchymal stem cellsmesenchymal stromal cellsparacrine communicationstem cellsstromal cells

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Main Results:

  • Friedenstein's foundational work established MSCs and aided in identifying other stem cell populations.
  • The concept of MSCs has evolved, with various terms used over time.
  • Emerging data reveal a mechanistic link between stromal functions and stem/progenitor capabilities.

Conclusions:

  • Friedenstein's contributions remain highly relevant to modern stem cell science.
  • Understanding MSC stromal quality is crucial for unifying the field.
  • Renewed focus on Friedenstein's work offers a path toward greater coherence in stem cell research.