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Platelets and Neurodegenerative Diseases: Current Knowledge and Future Perspectives.

Antonella Gallo1, Alice Lipari2, Silvino Di Francesco2

  • 1Department of Geriatrics, Orthopedics and Rheumatology, Fondazione Policlinico Universitario Agostino Gemelli, IRCCS, 00168 Rome, Italy.

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PubMed
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Platelets are increasingly recognized for their role in Alzheimer's disease (AD) and mild cognitive impairment (MCI) pathogenesis. Targeting platelet activation presents a novel therapeutic strategy for these neurodegenerative conditions.

Keywords:
Alzheimer’samyloidcognitive impairmentplatelets

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Area of Science:

  • Neuroscience
  • Immunology
  • Hematology

Background:

  • Platelets are crucial for hemostasis and thrombosis.
  • Emerging evidence highlights platelets' role in immune and inflammatory responses.
  • Platelets contribute to amyloid-beta (Aβ) deposition, implicated in Alzheimer's disease (AD).

Purpose of the Study:

  • To review the current understanding of platelet involvement in AD pathogenesis.
  • To explore the potential role of platelets in mild cognitive impairment (MCI).
  • To introduce platelet activation as a potential therapeutic target for AD and MCI.

Main Methods:

  • Literature review of studies on platelets, Aβ, AD, and MCI.
  • Analysis of existing research on platelet function in neuroinflammation.
  • Synthesis of evidence linking platelet activation to neurodegenerative processes.

Main Results:

  • Platelets play a significant role in the development of vascular amyloid-beta deposits in AD.
  • The potential involvement of platelets in MCI is under-explored.
  • Antiplatelet therapy shows promise for AD treatment/prevention, but requires more conclusive evidence.

Conclusions:

  • Platelet activation is a potential therapeutic target for both Alzheimer's disease and mild cognitive impairment.
  • Further research is needed to elucidate the precise mechanisms and validate therapeutic strategies.
  • Understanding platelet roles in neurodegeneration could lead to novel treatment approaches.