Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of the Platelet Plug01:22

Formation of the Platelet Plug

10.0K
The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
10.0K
Structure and Function of Platelets01:18

Structure and Function of Platelets

4.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

EIT in ARDS: what we know and what we still do not.

Intensive care medicine·2026
Same author

Investigating Performance, Functional Outcomes, and Patient Autonomy in a Rural Community Hospital: A Real-Life Descriptive Cohort Study of Territorial Intermediate Care.

Healthcare (Basel, Switzerland)·2026
Same author

PEEP and alveolar recruitment after 60 years of acute respiratory distress syndrome.

Intensive care medicine·2026
Same author

Airway Occlusions to Measure Inspiratory Effort, Respiratory Drive, and Lung Mechanics During Noninvasive Ventilation.

American journal of respiratory and critical care medicine·2026
Same author

Personalized automatic management of tracheal cuff pressure and subglottic secretions drainage to prevent pneumonia in critically ill intubated patients. The MICROINHALO multicenter randomized controlled trial.

Intensive care medicine·2026
Same author

Evaluating the Practical Impact of Fast Microbiology on the Treatment of Bloodstream Infections: Real-World Evidence from a High-Complexity Infectious Disease Center.

Antibiotics (Basel, Switzerland)·2026
Same journal

Five-Year Risk of CIN3+ After CIN1 Biopsy in a Norwegian Screening Setting: Comparison of CIN1 Diagnosed in a Single Calendar Year and in Two Consecutive Calendar Years.

Pathogens (Basel, Switzerland)·2026
Same journal

Ventilator-Associated Pneumonia (VAP) Prevention Bundle: A Multicenter Cross-Sectional Saudi Study to Assess Knowledge, Adherence, and Perceived Barriers Among ICU Practitioners in Hail Region.

Pathogens (Basel, Switzerland)·2026
Same journal

Anti-<i>Borrelia</i> IgG Seropositivity Among Hemodialysis Patients with Chronic Kidney Disease of Unknown Etiology: A Preliminary Case-Control Study from Northern Türkiye.

Pathogens (Basel, Switzerland)·2026
Same journal

Molecular Characterization of Hemotropic <i>Mycoplasma</i> spp. From Bats (Chiroptera) in the Northern Pantanal, Brazil.

Pathogens (Basel, Switzerland)·2026
Same journal

Characterization of Durum-Einkorn Amphiploids for Introgression of Powdery Mildew Resistance from Einkorn into Common Wheat.

Pathogens (Basel, Switzerland)·2026
Same journal

Human Orthohantavirus Infections: A Narrative Review.

Pathogens (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K

Early Platelet Dysfunction in Sepsis: An ICU Pilot Study.

Maria Grazia Bocci1, Silvia Sorrentino2, Ilaria Gatto2

  • 1Department of Clinical and Clinical Research, National Institute for Infectious Diseases Lazzaro Spallanzani, IRCCS, Via Portuense 292, 00149 Rome, Italy.

Pathogens (Basel, Switzerland)
|February 27, 2026
PubMed
Summary
This summary is machine-generated.

Platelet dysfunction, not just low platelet counts, is an early sign of sepsis severity. This dysfunction impacts both clotting and immune functions, offering a potential marker for timely intervention in septic patients.

Keywords:
SOFA scoreTEGplatelet dysfunctionprocalcitoninsepsisthrombocytopenia

More Related Videos

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K

Related Experiment Videos

Last Updated: Feb 28, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

1.7K
Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation
04:37

Comprehensive Analysis of Procoagulant Platelets Exhibiting Features of Necrosis, Apoptosis and Platelet Activation

Published on: May 23, 2025

1.2K
A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry
04:32

A Uniform Shear Assay for Human Platelet and Cell Surface Receptors via Cone-plate Viscometry

Published on: June 5, 2019

8.2K

Area of Science:

  • Hematology
  • Immunology
  • Critical Care Medicine

Background:

  • Platelets are vital for hemostasis and immune responses.
  • Thrombocytopenia in sepsis correlates with poor outcomes, but platelet dysfunction is less understood.
  • Sepsis involves complex interactions between coagulation, immunity, and organ function.

Purpose of the Study:

  • To investigate the relationship between platelet dysfunction and sepsis severity.
  • To assess both hemostatic and immune platelet functions in septic patients.
  • To determine if platelet dysfunction precedes or coincides with thrombocytopenia.

Main Methods:

  • Prospective observational pilot study involving 10 sepsis patients and 7 healthy controls.
  • Platelet function assessed using light transmission aggregometry (LTA), thromboelastography (TEG), P-selectin/PAC-1 expression, platelet-leukocyte aggregates, and soluble CD40L.
  • Blood samples collected at admission (T0), 48 hours (T1), and 7 days (T2).
  • Platelet function correlated with procalcitonin levels and SOFA scores.

Main Results:

  • Hemostatic and immune platelet dysfunctions were evident at admission (T0), preceding thrombocytopenia which occurred at T1.
  • Platelet function abnormalities correlated significantly with higher SOFA scores and procalcitonin levels at T0.
  • Early platelet dysfunction indicates sepsis severity.

Conclusions:

  • Early platelet dysfunction, occurring before thrombocytopenia, may serve as an early indicator of sepsis severity.
  • Assessing platelet function can guide timely interventions for hemostatic and immune abnormalities in sepsis.
  • Further research is warranted to explore the clinical utility of early platelet function assessment in sepsis management.