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Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
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Kidney Aging and Chronic Kidney Disease.
Yingying Zhang1,2, Chen Yu3, Xiaogang Li1,2
1Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
International Journal of Molecular Sciences
|June 27, 2024
Summary
Aging accelerates kidney disease development, sharing mechanisms like cellular senescence. Targeting these shared pathways may offer therapeutic benefits for both aging kidneys and chronic kidney disease (CKD).
Area of Science:
- Nephrology
- Gerontology
- Cellular Biology
Background:
- Aging is linked to increased chronic kidney disease (CKD) risk.
- CKD shares characteristics with accelerated aging.
- Kidney aging and CKD exhibit common pathological and mechanistic features.
Purpose of the Study:
- To review commonalities between aging kidneys and CKD.
- To explore shared underlying mechanisms.
- To discuss therapeutic strategies targeting cellular senescence.
Main Methods:
- Comprehensive literature review.
- Analysis of morphological and functional changes.
- Examination of molecular mechanisms.
Main Results:
- Aging kidneys and CKD share features like increased cellular senescence, reduced autophagy, mitochondrial dysfunction, and epigenetic alterations.
- These shared mechanisms highlight potential therapeutic targets.
- Cellular senescence is a key commonality.
Conclusions:
- Kidney aging and CKD are closely related, driven by common molecular pathways.
- Targeting cellular senescence presents a promising therapeutic avenue for both conditions.
- Further research into these shared mechanisms can advance treatments for age-related kidney decline.
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