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Related Concept Videos

Essential Minerals for Bone Health01:31

Essential Minerals for Bone Health

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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Updated: Jun 22, 2025

Analysis of Minerals Produced by hFOB 1.19 and Saos-2 Cells Using Transmission Electron Microscopy with Energy Dispersive X-ray Microanalysis
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Fish Bones as Calcium Source: Bioavailability of Micro and Nano Particles.

Benjamín Torres1, Alvaro Pérez1, Paula García1

  • 1Department of Nutrition, Faculty of Medicine, Universidad de Chile, Santiago 8380453, Chile.

Foods (Basel, Switzerland)
|June 27, 2024
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Summary

Salmon fish bone nanoparticles offer superior calcium bioavailability compared to microparticles and calcium carbonate. This research highlights a sustainable approach to waste reduction and novel calcium fortification in food.

Keywords:
bioavailabilitybonecalciumfishmicenanoparticles

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Area of Science:

  • Food Science
  • Biomaterials
  • Nutritional Science

Background:

  • Fish industry by-products constitute approximately 50% of waste.
  • Fish bones present an opportunity for valorization into novel calcium sources.
  • Nanoparticles derived from fish bones may offer enhanced bioavailability for food applications.

Purpose of the Study:

  • To compare the calcium bioavailability of salmon fish bone nanoparticles versus microparticles.
  • To evaluate salmon fish bone derived calcium against calcium carbonate as a calcium source.
  • To assess the potential of fish bone waste as a sustainable calcium supplement.

Main Methods:

  • A 21-day feeding study was conducted on male C57BL/6 mice (21-28 days old).
  • Experimental diets included varying concentrations (0.5% and 1.0% Ca) of calcium carbonate, salmon fish bone microparticles, and salmon fish bone nanoparticles.
  • Calcium bioavailability was determined by measuring calcium content in the femur.

Main Results:

  • Calcium bioavailability, indicated by femur calcium content, showed an increasing trend from calcium carbonate to salmon fish bone nanoparticles.
  • Salmon fish bone nanoparticles (NP 1.0) exhibited the highest calcium content compared to all other groups, except NP 0.5.
  • Salmon fish bone microparticles demonstrated better calcium bioavailability than calcium carbonate.

Conclusions:

  • Salmon fish bone nanoparticles significantly enhance calcium bioavailability compared to microparticles in a murine model.
  • Utilizing salmon fish bone nanoparticles presents a promising strategy for waste reduction and improved calcium delivery in the food industry.
  • This study validates the superior bioavailability of fish bone-derived calcium nanoparticles over conventional calcium sources.