Cardiovascular Disease and miRNAs: Possible Oxidative Stress-Regulating Roles of miRNAs

Area of Science:

• Biochemistry
• Molecular Biology
• Cardiology

Background:

• Cardiovascular diseases (CVD) are significantly influenced by oxidative stress, driven by reactive oxygen species (ROS).
• MicroRNAs (miRNAs) are increasingly recognized for their roles in disease pathogenesis, including CVD.
• Dysregulated miRNA expression is linked to the development and progression of cardiovascular conditions.

Purpose of the Study:

• To investigate the regulatory roles of microRNAs (miRNAs) in oxidative stress within the context of cardiovascular diseases (CVD).
• To provide mechanistic insights into how miRNAs modulate oxidative stress pathways relevant to CVD.
• To synthesize existing evidence on differentially expressed miRNAs and their validated targets involved in oxidative stress regulation in CVD.

Main Methods:

• This narrative review analyzes existing literature on microRNAs (miRNAs) and cardiovascular diseases (CVD).
• It focuses on differentially expressed miRNAs reported in various CVDs.
• The review examines empirically validated miRNA targets implicated in oxidative stress regulation.

Main Results:

• Evidence suggests a significant role for microRNAs (miRNAs) in regulating oxidative stress in cardiovascular diseases (CVD).
• Specific miRNAs and their targets have been identified as key modulators of oxidative stress pathways in CVD.
• Pathological miRNA expression contributes to both the development and progression of CVD through oxidative stress mechanisms.

Conclusions:

• MicroRNAs (miRNAs) are critical regulators of oxidative stress in cardiovascular diseases (CVD).
• Understanding these miRNA-mediated mechanisms is crucial for developing novel therapeutic strategies for CVD.
• Targeting specific miRNAs offers potential for managing oxidative stress and improving outcomes in cardiovascular conditions.