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Internal cellular stress, such as cellular injury or hypoxia, triggers intrinsic apoptosis. The B-cell lymphoma 2 (Bcl-2) family of proteins are the primary regulators of the intrinsic apoptotic pathway. For example, during DNA damage, checkpoint proteins, such as Ataxia Telangiectasia Mutated (ATM protein) and Checkpoints Factor-2 (Chk2) proteins, are activated. These proteins phosphorylate p53 which further activates pro-apoptotic proteins, such as Bax, Bak, PUMA, and Noxa, and inhibits...
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Selenomethionine Inhibited HADV-Induced Apoptosis Mediated by ROS through the JAK-STAT3 Signaling Pathway.

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|June 27, 2024
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Selenomethionine shows promise as an antiviral therapy by regulating oxidative stress and apoptosis pathways. This compound may offer a new treatment option for adenovirus (HAdV) infections, particularly in vulnerable populations.

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Area of Science:

  • Virology
  • Immunology
  • Biochemistry
  • Pharmacology

Background:

  • Adenovirus (HAdV) infections pose significant risks, causing severe respiratory illness in children and immunocompromised individuals.
  • Current therapeutic options for HAdV are limited, highlighting the urgent need for novel anti-adenoviral drugs.
  • Elemental selenium, particularly selenomethionine, exhibits antioxidant properties relevant to immune function.

Purpose of the Study:

  • To investigate the antiviral mechanism of selenomethionine against adenovirus (HAdV) infection.
  • To explore selenomethionine's role in modulating cellular processes related to viral replication and host response.
  • To assess selenomethionine as a potential therapeutic agent for HAdV.

Main Methods:

  • Evaluation of cell membrane integrity and intracellular DNA.
  • Measurement of cytokine secretion, mitochondrial membrane potential, and reactive oxygen species (ROS) production.
  • Analysis of apoptosis-related signaling pathways, including Jak1/2, STAT3, and BCL-XL.

Main Results:

  • Selenomethionine modulated the expression of Jak1/2, STAT3, and BCL-XL.
  • The compound influenced ROS production and regulated ROS-mediated apoptosis.
  • Inhibition of apoptosis was observed, suggesting a protective effect against HAdV-induced cell damage.

Conclusions:

  • Selenomethionine demonstrates an antiviral effect against adenovirus by regulating apoptosis through the modulation of specific signaling pathways.
  • The findings suggest that selenomethionine can improve the regulation of ROS-mediated apoptosis.
  • Selenomethionine presents a potential new therapeutic alternative for treating adenovirus infections.