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Related Concept Videos

Chromatin Structure Regulates pre-mRNA Processing02:41

Chromatin Structure Regulates pre-mRNA Processing

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In eukaryotic cells, nascent mRNA transcripts need to undergo many post-transcriptional modifications to reach the cell cytoplasm and translate into functional proteins. For a long time, transcription and pre-mRNA processing were considered two independent events that occur sequentially in the cell. However, it has now been well established that transcription and pre-mRNA processing are two simultaneous processes that are precisely regulated inside the cell.
The chromatin structure, especially...
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lncRNA - Long Non-coding RNAs02:39

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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Chromatin Position Affects Gene Expression02:35

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Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Chromatin Structure and RNA Splicing02:41

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Related Experiment Video

Updated: Jun 22, 2025

Chromatin Isolation by RNA Purification ChIRP
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Noncoding RNA-chromatin association: Functions and mechanisms.

Yafei Yin1, Xiaohua Shen2

  • 1Department of Cell Biology and Department of Cardiology of the Second Affiliated Hospital, Zhejiang University School of Medicine, Yuhangtang Road, Hangzhou, Zhejiang 310058, China.

Fundamental Research
|June 27, 2024
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Summary

Chromatin-associated noncoding RNAs (ncRNAs) regulate gene expression and chromatin structure. This review summarizes recent functional and mechanistic insights into these crucial molecules and discusses future research directions.

Keywords:
Chromatin associationChromatin structureGene expression regulationRepetitive RNAsncRNAs

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CARIP-Seq and ChIP-Seq: Methods to Identify Chromatin-Associated RNAs and Protein-DNA Interactions in Embryonic Stem Cells
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Chromatin Interaction Analysis with Paired-End Tag Sequencing ChIA-PET for Mapping Chromatin Interactions and Understanding Transcription Regulation
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Area of Science:

  • Genomics
  • Molecular Biology
  • Epigenetics

Background:

  • The mammalian genome is pervasively transcribed, generating numerous noncoding RNAs (ncRNAs).
  • A significant fraction of these ncRNAs are associated with chromatin.
  • These chromatin-associated ncRNAs are implicated in regulating gene expression and chromatin dynamics.

Purpose of the Study:

  • To review recent advances in understanding the function of chromatin-associated ncRNAs.
  • To explore the mechanistic basis of ncRNA association with chromatin.
  • To identify future challenges in the field of chromatin-associated ncRNAs.

Main Methods:

  • Literature review of functional studies.
  • Analysis of mechanistic insights into ncRNA-chromatin interactions.
  • Discussion of current research trends and limitations.

Main Results:

  • Noncoding RNAs play critical roles in cellular processes and disease.
  • Chromatin-associated ncRNAs are key regulators of gene expression.
  • Mechanisms of ncRNA binding and function at chromatin are being elucidated.

Conclusions:

  • Chromatin-associated ncRNAs are vital regulators of genome function.
  • Further research is needed to fully understand their diverse roles and mechanisms.
  • Overcoming current challenges will advance the field of ncRNA biology.