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Autophagy in chronic rhinosinusitis with or without nasal polyps
Jing Pei1, Zhaoran Ding1, Cheng Jiao2
1Department of Otolaryngology, Head and Neck Surgery, The Affiliated Jiangning Hospital With Nanjing Medical University, Nanjing, Jiangsu, China.
Frontiers in Cell and Developmental Biology
|June 27, 2024
Summary
Autophagy, a cellular process, is increasingly studied in chronic rhinosinusitis (CRS). Research suggests that manipulating autophagy may offer new therapeutic strategies for CRS and related inflammatory conditions.
Area of Science:
- Immunology
- Cellular Biology
- Otolaryngology
Background:
- Chronic rhinosinusitis (CRS) pathogenesis remains incompletely understood despite advances in basic research.
- Autophagy is implicated in various diseases, including inflammatory conditions and cancers.
- The role of autophagy in CRS, particularly with nasal polyps (NPs), is under investigation, with existing studies showing conflicting results.
Purpose of the Study:
- To review the current understanding of autophagy's role in chronic rhinosinusitis (CRS).
- To explore the potential of targeting autophagy as a therapeutic strategy for CRS.
Main Methods:
- Literature review of studies investigating autophagy in CRS.
- Analysis of existing research on autophagy in related inflammatory airway diseases.
Main Results:
- Conflicting findings exist regarding the precise role of autophagy in CRS pathophysiology.
- Autophagy modulation is proposed as a potential mechanism to regulate CRS-associated inflammation.
Conclusions:
- Further research is needed to clarify autophagy's complex role in CRS.
- Targeting autophagy presents a promising avenue for novel therapeutic interventions in chronic rhinosinusitis.
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