Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen...

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Wound Healing

Background:

• Diabetic wound healing is significantly impaired by infection and oxidative stress.
• Current treatments often struggle to address these complex challenges effectively.

Purpose of the Study:

• To develop a sustainable, hydrogen-producing hydrogel wound dressing for diabetic wounds.
• To investigate the antibacterial and antioxidant properties of the developed hydrogel for enhanced wound repair.

Main Methods:

• Constructed a hyaluronic acid-based hydrogel patch (HAP-Chl) incorporating poly(ionic liquid) (PIL) flocculated live Chlorella.
• Chlorella continuously produced hydrogen (H₂) for 24 hours under mild conditions.
• Evaluated antibacterial, antioxidant, biocompatible, and non-toxic properties of HAP-Chl.

Main Results:

• HAP-Chl demonstrated effective antibacterial activity against *Staphylococcus aureus* and significant antioxidant properties.
• The hydrogel promoted chronic wound healing by reducing reactive oxygen species (ROS), alleviating inflammation, and enhancing collagen deposition and angiogenesis.
• HAP-Chl exhibited biocompatible and non-toxic characteristics.

Conclusions:

• Developed a novel strategy for *in situ* sustainable hydrogen-producing hydrogels.
• HAP-Chl shows significant potential as an advanced antibacterial and antioxidant wound dressing for diabetic wounds.