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MXene-Based Conductive Microneedle Patch Promotes Diabetic Wound Healing by Regulating Oxidative Stress and Immune
Zhe Zhang1, Jie Shao2, Chunwen Lu3
1Department of Orthopedics, Affiliated Hospital 6 of Nantong University, The Third People's Hospital of Yancheng, Yancheng, Jiangsu224007, People's Republic of China.
ACS Applied Materials & Interfaces
|August 11, 2026
Summary
This study presents a novel MXene microneedle patch that accelerates diabetic wound healing. The patch reduces oxidative stress and inflammation by scavenging reactive oxygen species (ROS) and modulating immune responses.
Area of Science:
- Biomaterials Science
- Wound Healing Research
- Nanotechnology Applications
Background:
- Diabetic wounds exhibit impaired healing due to excessive reactive oxygen species (ROS) and inflammation.
- Endogenous electric fields show therapeutic promise for inflammatory wound treatment.
Purpose of the Study:
- To develop a conductive microneedle patch using MXene nanosheets for diabetic wound treatment.
- To investigate the dual mechanisms of ROS scavenging and electrical field modulation for enhanced wound repair.
Main Methods:
- Fabrication of a MXene nanosheet-based conductive microneedle patch.
- Evaluation of ROS scavenging and macrophage polarization (M2 phenotype) in vitro.
- Assessment of wound closure, inflammation suppression, and collagen deposition in a diabetic rat model.
Main Results:
- The MXene microneedle patch effectively scavenged ROS and promoted M2 macrophage polarization.
- In vivo studies showed significantly accelerated wound closure in diabetic rats.
- The patch suppressed local inflammation and enhanced collagen deposition at the wound site.
Conclusions:
- The developed MXene microneedle patch demonstrates a promising electro-chemical synergistic therapeutic strategy.
- This approach offers a novel treatment for chronic diabetic wounds by improving the wound microenvironment and immune response.
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