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Updated: Jun 22, 2025

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PTPRD gene variant rs10739150: A potential game-changer in hypertension diagnosis

Laith Al-Eitan1,2

  • 1Department of Biotechnology and Genetic Engineering, Faculty of Science and Arts, Jordan University of Science and Technology, Irbid, Jordan.

Plos One
|June 27, 2024
PubMed

Insights

Genetic variations in the PTPRD gene are linked to hypertension risk. The PTPRD rs10739150 G/G genotype and TTC haplotype may serve as potential biomarkers for hypertension susceptibility.

Area of Science:

  • Genetics
  • Cardiovascular Disease

Background:

  • Hypertension (HTN) is a complex disorder influenced by numerous physiological processes.
  • Understanding the genetic factors contributing to hypertension susceptibility is crucial due to its association with increased mortality.
  • This study investigated the genetic associations of 12 single nucleotide polymorphisms (SNPs) in seven candidate genes with hypertension.

Purpose of the Study:

  • To identify genetic associations between specific SNPs in candidate genes and hypertension in a Jordanian population.
  • To explore the potential role of PTPRD gene variants in hypertension development.

Main Methods:

  • A case-control study involving 200 Jordanian hypertension patients and 224 healthy controls.
  • DNA isolation and genotyping were performed on whole blood samples.
  • SNPStats tool was utilized to analyze genotype, allele, and haplotype frequencies using chi-square tests.

Main Results:

  • The PTPRD rs10739150 SNP showed a significant association with hypertension (P = 0.0003).
  • The G/G genotype of rs10739150 was more prevalent in hypertension patients (64.3%) than in controls (45.5%), indicating a potential risk factor.
  • PTPRD TTC genetic haplotypes were strongly associated with hypertension (P = 0.003, OR = 4.03).

Conclusions:

  • The PTPRD rs10739150 SNP plays a significant role in hypertension.
  • This finding offers potential for developing accurate diagnostic tools for identifying individuals at higher risk of hypertension.
  • The study enhances the understanding of the genetic underpinnings of hypertension.
Abstract

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