Related Experiment Video
Updated: Jun 22, 2025

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Reproducible Mouse Sciatic Nerve Crush and Subsequent Assessment of Regeneration by Whole Mount Muscle Analysis
Published on: February 22, 2012
33.8K
The "Genesis" of sciatic nerve injury
Zachary H Zamore1, Mark D Schuenke2, A Lee Dellon3
1Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Summary
Jacob
Area of Science:
- Biblical studies
- Anatomy
- Orthopedics
Background:
- Genesis 32 describes Jacob's encounter with an angel, resulting in a limp.
- Ancient understanding of anatomy did not differentiate between tendons and nerves.
Purpose of the Study:
- To determine the likely injury Jacob sustained based on the original Hebrew text of Genesis 32.
- To correlate the biblical description with modern medical understanding and practices.
Main Methods:
- Linguistic analysis of key terms in Genesis 32:25, 31, and 32.
- Application of anatomical and orthopedic knowledge to interpret the described injury.
Main Results:
- The angel likely injured Jacob's hip, not his thigh.
- The injury was probably a posterior hip dislocation with sciatic nerve damage.
- The term "sinew" likely refers to the sciatic nerve.
Conclusions:
- Jacob's limp was most likely caused by a posterior hip dislocation and sciatic nerve injury.
- The removal of the sciatic nerve in kosher butchery reflects this ancient biblical narrative.

