25 years of the IPD-IMGT/HLA Database

Area of Science:

• Immunogenetics
• Bioinformatics
• Genomic Data Management

Background:

• The IMGT/HLA Database has served as the primary repository for human leukocyte antigen (HLA) allele sequences since 1998.
• It has been curated by the WHO Nomenclature Committee for Factors of the HLA System, ensuring standardized naming conventions.
• The database has provided a stable and accessible resource for researchers globally.

Purpose of the Study:

• To highlight the evolution of the IMGT/HLA Database over 25 years.
• To discuss the challenges and adaptations in managing increasing sequence data due to technological advancements.
• To emphasize the database's continued role in supporting HLA research.

Main Methods:

• The study reviews the historical development and ongoing curation processes of the IMGT/HLA Database.
• It discusses the impact of next-generation sequencing (NGS) on data submission and complexity.
• The adaptation of data access and presentation methods using new computing technologies is examined.

Main Results:

• The IMGT/HLA Database has successfully managed a significant increase in the number and complexity of HLA sequences.
• The database has maintained high curation standards despite technological shifts.
• New methods have been developed to support a changing user demographic and increased data volume.

Conclusions:

• The IPD-IMGT/HLA Database has demonstrated resilience and adaptability over 25 years.
• It continues to be a vital resource for HLA research, evolving with technological advancements.
• Ongoing development is crucial to support the growing needs of the scientific community.